Hth-01-015

Author: dagb

August undefined, 2024

Web中文名称：HTH-01-015. CAS号：1613724-42-7. 分子量：.00. 标准纯度：95+%. SMILES：CC1=C2C (=NC (=N1)NC3=CN (C4CCNCC4)N=C3)N (C)C5=C … Web8 apr. 2024 · However, even with long term administration of antiviral HTH-01-015 providers, the incidence of HZ raises after discontinuation of prophylaxis [4, 13]. Although necessary, there is not plenty of evidence to support a minimum interval between transplantation and …

HTH-01-015 AMPK Inhibitor MedChemExpress

Web1 sep. 2024 · The compounds WZ4003 and HTH-01-015 are known inhibitors of NUAK1, indicating that residues Gly64, Val69, Gly138, and Asp196 of NUAK1 may be important … WebWe observed that HTH-01-015 treatment drastically changed the mitochondria morphology of MCF-7 cells, from mainly networked and tubular to large and round mitochondrial structure (Figures 4B,C). Interestingly, mitotracker green images showed a mitochondrial structure known as “donut” rather than the typical punctate mitochondrion . To ... powell medical foundation

HTH01015是一高效_价格-品牌-详情介绍_丁香通

WebHTH-01-015 impaired the invasive potential of U2OS cells in a 3D cell invasion assay to the same extent as NUAK1 knockdown. HTH-01-015 will serve as useful chemical probes to … WebHTH-01-015 是一种有效的选择性 NUAK1 抑制剂，比作用于NUAK2的选择性高100多倍。 Quality confirmed by NMR & HPLC. See customer reviews, validations & product citations. WebHTH 01-015 is a potent and selective NUAK1 inhibitor (IC 50 = 100 nM). Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. … powell mechanical services

Frontiers Cytosolic NUAK1 Enhances ATP Production by …

Web28 okt. 2024 · Notably, we demonstrated in a mouse model that targeting ARK5 with the selective inhibitor HTH-01-015 attenuates CCl4-induced liver fibrosis in mice. Taken together, the results indicate that ARK5 is a critical driver of liver fibrosis, and promotes liver fibrosis by synergy between HSCs and hepatocytes. Keywords: WebHTH-01-015 suppresses cell migration In NUAK1+/+ MEFs, and inhibit U2OS cell invasion. Moreover, HTH-01-015 inhibits cell proliferation in both cell lines. HTH-01-015 inhibitors … towell brothers custom homesWeb6 nov. 2024 · Death induced by 10 μ m HTH-01-015 was significantly attenuated by reducing MYC levels with either of two MYC-targeting shRNAs , consistent with our … towell and shine

"WebHTH-01-015 has an IC 50 of 100 nM for NUAK1, >100-fold higher than NUAK2, and has no significant inhibition of 139 other kinases tested, including ten AMPK-related kinase … " - Hth-01-015

Hth-01-015

WebHTH-01-015. Synonym (s): 5,13-Dihydro-4,5,13-trimethyl-2- [ [1- (4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho [2,3-e]pyrimido [5,4-b] [1,4]diazepin-6-one. Empirical Formula … Web22 mrt. 2024 · Consistent with PTEN-SSL status, inhibition of the NUAK1 protein kinase by the small molecule drug HTH-01-015 selectively impaired viability in multiple PTEN …

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Web8 mrt. 2024 · XMD-17-51 trifluoroacetate, a pyrimido-diazepinone compound, was originally discovered as a derivative of HTH-01-015, which is a selective inhibitor of NUAK1 … Webhth-01-015是一种高特异性和高选择性的nuak1抑制剂，ic50值为100 nm[1]。 hth-01-015只抑制nuak激酶家族中的nuak1亚型，而对其它被测试的139个激酶没有显著的抑制活性 …

WebHTH-01-015 is a highly specific inhibitor of NUAK1 with IC50 value of 100 nM 1. HTH-01-015 showed extreme selectivity. It only inhibited the NUAK1 (NUAK family SNF1-like … WebHTH-01-015 是一种选择性 NUAK1 抑制剂，IC50为 100 nM。. 它抑制 NUAK1 的效力比抑制 NUAK2 高 100 倍以上，IC50大于10 μM。. TargetMol的所有产品和服务仅用于科学研 …

WebHTH-01-015 Solid 2887-5: 5 mg 2887-25: 25 mg See below SECTION 3: HAZARDS IDENTIFICATION Components CAS Number EC-No. Molecular Weight Chemical Formula HTH-01-015 1613724 -42 7 -- 468.55 C 26 H 28 N 8 O HTH-01-015: Emergency Overview: OSHA Hazards: No known OSHA hazards GHS Classification: Not a dangerous … Web11 jan. 2024 · hth-01-015是一种特异性的nuak1抑制剂。相关的nuak1和nuak2是ampk（amp激活的蛋白激酶）蛋白激酶家族的成员，其被lkb1（肝激酶b1）肿瘤抑制激 …

WebConsistent with PTEN-SSL status, inhibition of the NUAK1 protein kinase by the small molecule drug HTH-01-015 selectively impaired viability in multiple PTEN-deficient …

Web1 jan. 2014 · WZ4003 and HTH-01-015 suppress NUAK1-mediated MYPT1 phosphorylation. To evaluate whether WZ4003 and HTH-01-015 could suppress NUAK activity in vivo, we … powell mechanical pittsburghWebFurthermore, the NUAK1 PTEN-SSL vulnerability identified by RNA interference techniques can be recapitulated and exploited using the small molecule kinase inhibitor HTH-01-015. Thus, NUAK1... towel largeWebHTH-01-015 is a highly specific inhibitor of NUAK1 with IC50 value of 100 nM 1. HTH-01-015 showed extreme selectivity. It only inhibited the NUAK1 (NUAK family SNF1-like … towel laundry service londonWebName: HTH-01-015 CAS#: 1613724-42-7 Chemical Formula: C26H28N8O Exact Mass: 468.2386 Molecular Weight: 468.565 Elemental Analysis: C, 66.65; H, 6.02; N, 23.91; O, … powell mechanical victoria vaWebHTH-01-015 is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. Availability: In stock Free Overnight Delivery on orders over $500 Next day delivery by 10:00 a.m. Order now. Add to Cart Bulk Inquiry Price Match Add to Wishlist towel laundry cycleWebTGF-β is a growth factor implicated in a plethora of processes and malignancies, which include cancer and fibrosis. Via binding to its receptor, TGF-β activates a complex intracellular signal transduction pathway, which is controlled by many forms of positive as well as negative feedback. towel lampWeb4 feb. 2024 · hth-01-015 是一种有效的选择性nuak1抑制剂,其ic50为100 nm,比作用于nuak2的选择性高100多倍。 cas: 1613724-42-7 规格价格库存购买数量 5mgrmb 807.53 … powell meeting live